I think sometimes when people get caught up in a purely emperical world-view, they miss the big picture. They miss the point of it all. They try to find the objective truth of reality, independent of self, as if self is something that is completely separate from reality. Yet the scientific community themselves will say that we are the product of what we came from, evolutionarily speaking. We, then, work under the same fundamental principles reality works under. When you really delve in to the assumption that people who take the self aspect out of it, as if we are nothing, you see that it sounds more religious than a spiritual world view. They say that their world-views have nothing to do with reality, or truth. This is to make the assumption that our minds work in ways that defy natural law. This is simply not the case. Whatever it is that the universe functions through, our minds, and our evolution, works through too. This means that self-exploration is equally valid to emperical evidence. Our minds, who we are, are working under the same essential principles that all of reality is.